Under Activity Monitor, find the entry for Advanced Mac Cleaner, select it and click Quit Process. Locate the Activity Monitor icon on the screen and double-click on it. Advanced Mac Cleaner manual removal for Mac Open up the Utilities folder as shown below. Follow these step-by-step instructions to ensure complete uninstallation of the above app: Make sure all the necessary files are backed up before uninstalling Advanced Mac Cleaner. The easiest way to remove Advanced Mac Cleaner tool is by using Mac’s native functionality.